Bacteria Shifts that are Statistically Significant for Autism

Recently I have been updating the statistic processing for association though diverse methods. Everything below is P < 0.005 (or 1 in 200 of happening at random).

From Ombre data

BacteriaRankShift
Bifidobacterium bifidumspeciesToo High
Bifidobacterium subtilespeciesToo High
HungateiclostridiaceaefamilyToo High
LiquorilactobacillusgenusToo High
Liquorilactobacillus vinispeciesToo High
NeisseriaceaefamilyToo High
Peptoniphilus obesispeciesToo Low
SenegalimassiliagenusToo High
unclassified ClostridialesfamilyToo High

From Biomesight Data

One note, we do 4 different computations and in general they agree with each other (the Monte Carlo or Consensus Model). For Bifidobacterium species, that is not the case, some computations suggests too high and other computations suggests too low. Bifidobacterium with Autism have a variety of disagreements between studies. In this case, we know that the disagreement is due to the statistical method used.

As seen below, there is over prevalence (seen more often), but the values are smaller than the reference population.

BacteriaRankStatistical TestP ValueShift
Bifidobacterium angulatumspeciesChi-2 prevalence3.21E-12Too High
Bifidobacterium angulatumspeciesMann_Whitney_Wilcoxon0.000456655Too Low
Bifidobacterium angulatumspeciesAverages0.000464826Too Low

BacteriaRankShift
AbsiellagenusToo High
AcidaminococcusgenusToo High
ActinomycesgenusToo Low
ActinomycetaceaefamilyToo Low
ActinomycetesclassToo Low
ActinomycetotaphylumToo Low
AgromycesgenusToo High
Agromyces salentinusspeciesToo High
AmoebophilaceaefamilyToo High
AnaerotruncusgenusToo High
Anaerotruncus colihominisspeciesToo High
AnaerovibriogenusToo High
Anaerovibrio lipolyticusspeciesToo High
BacteroidesgenusToo High
Bacteroides cellulosilyticusspeciesToo High
Bacteroides faecisspeciesToo High
Bacteroides finegoldiispeciesToo High
Bacteroides fragilisspeciesToo Low
Bacteroides rodentiumspeciesToo High
Bacteroides stercorirosorisspeciesToo High
Bacteroides thetaiotaomicronspeciesToo High
Bacteroides uniformisspeciesToo High
BifidobacteriaceaefamilyToo Low
BifidobacterialesorderToo Low
BifidobacteriumgenusToo Low
Bifidobacterium adolescentisspeciesToo Low
Bifidobacterium angulatumspeciesToo High
Bifidobacterium angulatumspeciesToo Low
Bifidobacterium bifidumspeciesToo Low
Bifidobacterium catenulatumspeciesToo High
Bifidobacterium catenulatumspeciesToo Low
Bifidobacterium catenulatum PV20-2strainToo High
Bifidobacterium catenulatum PV20-2strainToo Low
Bifidobacterium catenulatum subsp. kashiwanohensesubspeciesToo High
Bifidobacterium catenulatum subsp. kashiwanohensesubspeciesToo Low
Bifidobacterium choerinumspeciesToo Low
Bifidobacterium cuniculispeciesToo High
Bifidobacterium gallicumspeciesToo High
Bifidobacterium gallicumspeciesToo Low
Bifidobacterium indicumspeciesToo High
Bifidobacterium indicumspeciesToo Low
Bifidobacterium longumspeciesToo Low
Bifidobacterium scardoviispeciesToo High
Bifidobacterium subtilespeciesToo Low
BurkholderiagenusToo Low
Burkholderiales genera incertae sedisno rankToo Low
Caloramator fervidusspeciesToo High
Caloramator indicusspeciesToo High
Candidatus AmoebophilusgenusToo High
Candidatus Amoebophilus asiaticusspeciesToo High
Candidatus BlochmanniellagenusToo High
Candidatus Blochmanniella camponotispeciesToo High
ClostridiumgenusToo High
Clostridium chartatabidumspeciesToo High
Clostridium thermosuccinogenesspeciesToo High
Collinsella aerofaciensspeciesToo Low
CoriobacteriiaclassToo Low
DesulfotomaculaceaefamilyToo High
DesulfovibriogenusToo High
DesulfuromonadaceaefamilyToo Low
DesulfuromusagenusToo Low
EnterobactergenusToo Low
Enterobacter cloacae complexspecies groupToo High
Enterobacter hormaecheispeciesToo High
EnterobacteralesorderToo Low
EnterobacteriaceaefamilyToo Low
Enterobacteriaceae incertae sedisno rankToo High
ErysipelothrixgenusToo High
EscherichiagenusToo Low
Escherichia colispeciesToo Low
EukaryotasuperkingdomToo Low
GammaproteobacteriaclassToo Low
GeopsychrobacteraceaefamilyToo Low
HathewayagenusToo High
Hathewaya histolyticaspeciesToo High
HungateiclostridiaceaefamilyToo High
HungateiclostridiumgenusToo High
HydrogenophilaceaefamilyToo Low
HydrogenophilalesorderToo Low
HydrogenophiliaclassToo Low
Klebsiella oxytocaspeciesToo High
MegamonasgenusToo High
MegamonasgenusToo Low
Megamonas funiformisspeciesToo High
Megamonas funiformisspeciesToo Low
Moorella groupnorankToo High
OscillospiragenusToo High
ParascardoviagenusToo High
ParascardoviagenusToo Low
PedobactergenusToo High
PeptoniphilaceaefamilyToo High
PeptoniphilusgenusToo High
Phascolarctobacterium succinatutensspeciesToo High
PhocaeicolagenusToo High
Phocaeicola paurosaccharolyticusspeciesToo High
Phocaeicola sartoriispeciesToo High
Phocaeicola vulgatusspeciesToo High
PorphyromonasgenusToo High
PseudoclostridiumgenusToo High
RhodothermalesorderToo High
RhodothermiaclassToo High
RhodothermotaphylumToo High
SarcinagenusToo Low
Sarcina maximaspeciesToo Low
SegatellagenusToo Low
Segatella albensisspeciesToo Low
Segatella coprispeciesToo Low
Segatella oulorumspeciesToo High
SelenomonasgenusToo High
Selenomonas infelixspeciesToo High
SphingobacteriaceaefamilyToo High
SphingobacterialesorderToo High
SphingobacteriiaclassToo High
Sphingobacterium bambusaespeciesToo High
Streptococcus intermediusspeciesToo High
Streptococcus mutansspeciesToo High
Streptococcus thermophilusspeciesToo Low
ThiomonasgenusToo Low
TissierellalesorderToo High
unclassified Bacteroidetes Order II.orderToo High
VeillonellagenusToo Low
Veillonella montpellierensisspeciesToo Low

High Functioning Autism

We have smaller sample size, but do have some significant items

Ombre Data

BacteriaRankShift
Butyricimonas paravirosaspeciesToo High
HallellagenusToo High
Hallella multisaccharivoraxspeciesToo High
Hoylesella oralisspeciesToo High
Hoylesella timonensisspeciesToo High
LeyellagenusToo High
Leyella stercoreaspeciesToo High
Segatella baroniaespeciesToo High
Segatella maculosaspeciesToo High
Xylanibacter brevisspeciesToo High

Biomesight Data

BacteriaRankShift
Bilophila wadsworthiaspeciesToo Low
ErysipelothrixgenusToo Low
Erysipelothrix murisspeciesToo Low
HoldemaniagenusToo Low

I will revisit as more data comes in.

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