Acetaminophen and Autism do not mix. Since 2008, there should have been warning not to give children Acetaminophen after a vaccination:

 Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey. [2008]

Pregnant mothers should have been warned against using Acetaminophen. ASD children should not be given it.

• Standard Medical Advice “The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy.” [2018 Article]
• “Acetaminophen use in children has been associated with increased autism risk” [2010 Study]
• “Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.” [2018 Study]
• Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males.[2020] “Using this data set, the PAF associated with postnatal acetaminophen was estimated to be about 40% of the risk of ASD among male children in the US. These results suggest the possibility that postnatal acetaminophen may be a significant contributor to the risk of ASD among males in the US.”
• “Cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD in a dose-response fashion.” [2019 Study]
• “these nine studies suggest an increased risk of adverse neurodevelopmental outcomes following prenatal paracetamol (acetaminophen) exposure” [2018 Study]
• “Acetaminophen use in childhood was associated with autism spectrum disorder, asthma symptoms, wheezing, and allergic disease. ” [2017 Study]
• “This view mandates extreme urgency in probing the long-term effects of acetaminophen use in babies and the possibility that many cases of infantile autism may actually be induced by acetaminophen exposure shortly after birth.” [2017 Study]
• “Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure.” [2016 Study]
• “Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. ” [2015 Study]
• “We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children.” [2016 Study]

Direct impact on Social Behavior

• A recent study by Mischkowski, Crocker, and Way (Soc Cogn Affect Neurosci 11: 1345-1353, 2016) provides novel insights into neurobiological underpinnings of empathy by demonstrating that acetaminophen, a widely used painkiller, reduces empathy for other’s physical and social pain. [2017 Study]

Microbiome Impact

Using published study data, we find that acetaminophen has a strong adverse impact on the microbiome changes seen with autism. That is, it causes the abnormal shifts to increase further.