Organic Acids Tests (OATS) and Autism #1

The last of the test results forwarded by a reader was the Great Plains Laboratory Organic Acid Test. The two earlier tests results with comments are:

There are a lot of tables in this report and I will do just 1-2 in each blog post to keep information flow manageable.

This test is interesting because it lists some of the bacteria associated associated various markers.

This page lists OVERGROWTH — there is only one that is high (overgrowth). Items being low should likely be ignored.

The one interesting thing is that most of the lows are associated to Aspergillus. This agrees with a study that I cited earlier:

“Saccharomyces and Aspergillus showed significant differences between ASD (59.07%) and Control (40.36%), indicating that they may be involved in the abnormal gut fungal community structure of ASD. When analyzed at the species level, a decreased abundance in Aspergillus versicolor was observed while Saccharomyces cerevisiae was increased in children with ASD relative to controls. ” [2020]

 Aspergillus oryzae is the only Aspergillus that I know that is available as a probiotic (Strong Wakamoto W)

 2-Hydroxyphenylacetic Acid is shown as high above. The literature mentions 3-Hydroxyphenylacetic Acid is common with Autism

Nutritional Markers

The item that stands out is thiamin and there is no literature connecting it to autism beyond lower intake by diet in some locations.

  • Autism spectrum disorder group failed to meet dietary recommendations for thiamin, riboflavin, vitamin C, or calcium. [2017]

From this article Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity [2011] we read:

  • No statistical difference for Thiamin
  • No statistical difference for Riboflavin
  • No statistical difference for Niacin
  • No statistical difference for Pantothenic Acid, but average was lower
  • No statistical difference for Vitamin C

I should add one word of warning, because the levels were similar, it does no exclude supplementation as being beneficial in some cases. The reason is that often they are processed into other chemicals (depending on available surplus and the bacteria present).

N-acetylcysteine (NAC) is more interesting because the marker indicate it was high. For a subset of ASD patients (high irritability), supplementation helps:

CoQ 10 is shown as low above. As with NAC, supplementation appears to benefit a subset.

Bottom Line

My working model is that symptoms are strongly associated to the metabolites (chemicals/vitamins) produced/processed by the microbiome (bacteria in digestive system). For CoQ10 and NAC, we know the bacteria that are likely impacted, and that information is linked to here (CoQ10 , NAC).

This means that it is not a one-size fit all approach to autism, but very individual – either based on symptoms OR on the microbiome. I am biased towards using the microbiome (16s reports from Biome Sight [“MICRO” as discount code], followed by Thryve Inside)